ONCASPAR3750IU

ONCASPAR dosing should always be determined by a qualified hematologist/oncologist as part of a comprehensive ALL treatment protocol:

Standard Dosing:

• **Intramuscular (IM) or Intravenous (IV):** 2,500 IU/m² body surface area

• **Frequency:** Every 14 days (as part of multi-agent chemotherapy)

• **Maximum single dose:** Typically not to exceed manufacturer recommendations

Administration Route:

• **Intramuscular (IM):** Preferred route in many protocols; inject into large muscle mass

• **Intravenous (IV):** Administer over 1-2 hours; do not give as bolus injection

Treatment Phases:

ONCASPAR is typically incorporated into various phases of ALL treatment:

• **Induction Phase:** Initial intensive treatment to achieve remission

• **Consolidation Phase:** Deepening remission after initial response

• **Delayed Intensification:** Additional intensive therapy phase

• **Maintenance:** Some protocols include during maintenance

Important Considerations:

• Premedication may be required to prevent infusion reactions

• Monitor for signs of hypersensitivity during and after administration

• Regular monitoring of pancreatic enzymes, coagulation, and liver function required

• Dose modifications may be needed based on toxicity

For Patients Previously Hypersensitive to E. coli Asparaginase:

ONCASPAR may be used in patients who have had allergic reactions to native E. coli L-asparaginase, though careful monitoring is essential.

*Note: One ONCASPAR vial contains 3,750 IU in 5 mL (750 IU/mL). Dosing is individualized based on body surface area.*

ONCASPAR requires strict cold chain storage to maintain stability and efficacy:

Storage Temperature:

• Store refrigerated at 2°C to 8°C (36°F to 46°F)

• Do NOT freeze

• Do NOT shake vigorously

Protect from Light:

• Keep in original carton until time of use

• Protect from bright light

Handling:

• For single use only

• Discard any unused portion

• Do not use if solution is cloudy, discolored, or contains particles

• Solution should be clear and colorless

Reconstitution/Dilution:

• Withdraw the calculated dose from the vial

• For IV administration: Dilute in 100 mL of 0.9% Sodium Chloride or 5% Dextrose

• Use diluted solution within 4 hours (room temperature) or 24 hours (refrigerated)

Transportation:

• Must maintain cold chain (2-8°C) during transport

• Use validated cold chain packaging with temperature monitoring

• Do not accept delivery if temperature excursion is suspected

Shelf Life:

• Check expiration date on packaging

• Do not use beyond expiration date

*Pharmacy Remedy ensures all ONCASPAR shipments maintain proper cold chain protocols with temperature monitoring and validated packaging for international delivery.*