Where can I buy ZYTIGA 500mg online?

Pharmacy Remedy provides genuine Janssen ZYTIGA 500mg tablets with worldwide delivery. We supply urology practices, hospitals, and distributors. Contact us via WhatsApp at +44 7429 917553 for pricing.

What is the difference between ZYTIGA 500mg and 250mg?

ZYTIGA 500mg is a new formulation taken ONCE daily WITH FOOD. The original 250mg requires FOUR tablets on an EMPTY stomach. Both deliver the same total dose (1000mg/day) but 500mg offers superior convenience.

Why must ZYTIGA be taken with prednisone?

ZYTIGA inhibits CYP17A1, which is also needed for cortisol synthesis. Blocking cortisol triggers compensatory ACTH increase, leading to mineralocorticoid excess (hypertension, hypokalemia). Prednisone replaces cortisol and prevents these effects.

What are the side effects of ZYTIGA?

Common side effects include joint swelling/discomfort, hypokalemia (low potassium), edema, muscle discomfort, hot flush, hypertension, and fatigue. Liver function and potassium levels require regular monitoring.

How effective is ZYTIGA for prostate cancer?

Clinical trials showed ZYTIGA significantly improves overall survival in both post-chemotherapy and chemotherapy-naive mCRPC. Median survival improved by approximately 4 months in COU-AA-301 and was not even reached in COU-AA-302 at initial analysis.

Can ZYTIGA be used with other prostate cancer drugs?

ZYTIGA is used with ongoing ADT (androgen deprivation therapy). It is not typically combined with other next-generation hormonal agents like enzalutamide. It can precede or follow chemotherapy depending on clinical situation.

ZYTIGA

500mg

Oncology Medications

ZYTIGA500mg

Name: ZYTIGA 500mg
Brand: Janssen
SKU: zytiga-500mg
Availability: InStock

ZYTIGA (abiraterone acetate) 500mg is a next-generation androgen synthesis inhibitor for metastatic castration-resistant prostate cancer, offering convenient once-daily dosing.

Generic Name:Abiraterone

Manufacturer:Janssen

Key Benefits

Next-generation androgen synthesis inhibitor
Convenient once-daily 500mg dosing with food
Significant overall survival improvement
Works in castration-resistant disease
Blocks androgens from all sources
Oral tablet—home administration

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How ZYTIGA Works

ZYTIGA works by selectively and irreversibly inhibiting CYP17A1 (17α-hydroxylase/C17,20-lyase), a crucial enzyme complex required for androgen biosynthesis.

**Androgen Synthesis Pathway:** CYP17A1 catalyzes two key reactions in androgen synthesis: conversion of pregnenolone to 17-OH-pregnenolone (17α-hydroxylase activity) and conversion of 17-OH-pregnenolone to DHEA (C17,20-lyase activity).

**Why This Matters:** Even after castration removes testicular androgen production, the adrenal glands and prostate tumor cells themselves can produce androgens that fuel prostate cancer growth. ZYTIGA blocks androgen production from all these sources.

**Result:** Near-complete suppression of androgens leads to tumor shrinkage and delayed progression. The addition of prednisone prevents mineralocorticoid excess caused by CYP17A1 inhibition.

About ZYTIGA 500mg

ZYTIGA (abiraterone acetate) 500mg by Janssen represents the convenient once-daily formulation of this groundbreaking androgen synthesis inhibitor. ZYTIGA revolutionized prostate cancer treatment by demonstrating that even castration-resistant disease remains sensitive to further androgen suppression. The 500mg tablet formulation (taken as one tablet daily with food) simplifies dosing compared to the original 250mg formulation (four tablets daily without food). This improved convenience supports better treatment adherence. ZYTIGA inhibits CYP17A1, an enzyme required for androgen biosynthesis in the testes, adrenal glands, and prostate tumor tissue. By blocking androgen production at all these sites, ZYTIGA provides more complete androgen suppression than castration alone. Clinical trials including COU-AA-301 and COU-AA-302 demonstrated significant improvements in overall survival for both post-chemotherapy and chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). ZYTIGA is also approved for metastatic high-risk castration-sensitive prostate cancer (mCSPC). Pharmacy Remedy provides authentic Janssen ZYTIGA for urology and oncology practices worldwide.

Common Uses

Metastatic castration-resistant prostate cancer (mCRPC)
Metastatic high-risk castration-sensitive prostate cancer (mCSPC)
Pre-chemotherapy mCRPC
Post-chemotherapy mCRPC

Dosage Information

ZYTIGA 500mg Tablets (with food):

500 mg (one tablet) orally once daily with food

Must take with prednisone 5 mg twice daily

Alternative: ZYTIGA 250mg Tablets (without food):

1000 mg (four tablets) orally once daily on empty stomach

Take with prednisone 5 mg twice daily

Important:

500mg formulation MUST be taken with food

250mg formulation MUST be taken on empty stomach

Continue ADT (GnRH agonist/antagonist or bilateral orchiectomy)

Hepatic Impairment:

Mild: No adjustment

Moderate: 250 mg once daily

Severe: Avoid use

Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.

Storage & Handling

Store ZYTIGA tablets at 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C and 30°C (59°F and 86°F). Store in original container. No cold chain required.

We ensure proper cold chain handling during shipping to maintain product integrity.