Where can I buy XTANDI 40mg online?

Pharmacy Remedy supplies genuine Pfizer XTANDI 40mg capsules with worldwide delivery. We provide competitive wholesale pricing for hospitals, clinics, and distributors. Contact us via WhatsApp at +44 7429 917553.

What is XTANDI used for?

XTANDI is FDA-approved for metastatic castration-resistant prostate cancer (mCRPC), non-metastatic castration-resistant prostate cancer (nmCRPC) with high risk of metastasis, and metastatic castration-sensitive prostate cancer (mCSPC).

How is XTANDI different from ZYTIGA?

XTANDI blocks the androgen receptor directly, while ZYTIGA blocks androgen synthesis. XTANDI advantages: no prednisone required, can be taken with food. ZYTIGA advantages: 500mg is once-daily (XTANDI is 160mg = 4 capsules). Both are highly effective.

What are the side effects of XTANDI?

Common side effects include fatigue, hot flashes, diarrhea, musculoskeletal pain, headache, and hypertension. Serious but rare side effects include seizures (rare, <1%), falls, and cognitive effects. XTANDI does not cause mineralocorticoid excess like ZYTIGA.

Does XTANDI cause seizures?

Seizure risk is low (<1%) but XTANDI should be used with caution in patients with seizure history or risk factors. Patients should avoid activities where sudden loss of consciousness could cause serious harm.

How effective is XTANDI for prostate cancer?

Clinical trials show XTANDI significantly improves overall survival, delays metastasis (in nmCRPC by over 2 years), and delays PSA progression across all approved indications.

XTANDI

40mg

Oncology Medications

XTANDI40mg

Name: XTANDI 40mg
Brand: Astellas
SKU: xtandi-40mg
Availability: InStock

XTANDI (enzalutamide) 40mg is a potent androgen receptor inhibitor for treating metastatic and non-metastatic castration-resistant prostate cancer with proven survival benefits.

Generic Name:Enzalutamide

Manufacturer:Astellas

Key Benefits

Potent next-generation androgen receptor inhibitor
No prednisone requirement
Flexible dosing—with or without food
Proven survival benefits across multiple settings
Works in both metastatic and non-metastatic CRPC
Also approved for metastatic hormone-sensitive disease

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How XTANDI Works

XTANDI inhibits androgen signaling at multiple steps:

**1. Competitive AR Binding:** Binds to the androgen receptor with 5-8 times greater affinity than bicalutamide, preventing testosterone and DHT from activating the receptor.

**2. Blocks Nuclear Translocation:** Prevents the AR from moving into the cell nucleus where it would activate gene transcription.

**3. Inhibits DNA Binding:** Prevents AR from binding to DNA even if it reaches the nucleus.

**4. Prevents Coactivator Recruitment:** Blocks recruitment of factors needed for AR-mediated gene expression.

This comprehensive blockade is more effective than older antiandrogens that only block ligand binding. XTANDI remains active against AR splice variants and overexpressed AR that can cause resistance to older antiandrogens.

About XTANDI 40mg

XTANDI (enzalutamide) 40mg by Pfizer (originally Astellas) is a next-generation androgen receptor (AR) inhibitor that has become a cornerstone of prostate cancer treatment. Unlike older antiandrogens, XTANDI binds the AR with much higher affinity and blocks multiple steps in androgen signaling. XTANDI is FDA-approved for both metastatic and non-metastatic castration-resistant prostate cancer (CRPC), as well as metastatic castration-sensitive prostate cancer (mCSPC). This broad indication range makes it one of the most widely used prostate cancer therapies. The AFFIRM and PREVAIL trials demonstrated significant overall survival improvements in mCRPC. The PROSPER trial showed XTANDI delayed metastasis by over two years in non-metastatic CRPC. The ARCHES and ENZAMET trials established its role in metastatic castration-sensitive disease. XTANDI offers advantages over ZYTIGA including no requirement for prednisone co-administration and no food restrictions. Pharmacy Remedy provides authentic Pfizer XTANDI for urology and oncology practices worldwide.

Common Uses

Metastatic castration-resistant prostate cancer (mCRPC)
Non-metastatic castration-resistant prostate cancer (nmCRPC)
Metastatic castration-sensitive prostate cancer (mCSPC)
Post-chemotherapy mCRPC
Pre-chemotherapy mCRPC

Dosage Information

Standard Dosing:

160 mg (four 40mg capsules) orally once daily

Can be taken with or without food

No prednisone required

Administration:

Swallow capsules whole

Take at approximately same time each day

Continue ADT (unless bilateral orchiectomy)

Dose Modifications:

For severe toxicity: reduce to 80 mg or 120 mg once daily

Drug interactions: avoid strong CYP2C8 inhibitors; if needed, reduce to 80 mg

Duration:

Continue until disease progression or unacceptable toxicity

Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.

Storage & Handling

Store XTANDI capsules at 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C and 30°C (59°F and 86°F). Keep in original container. No cold chain required.

We ensure proper cold chain handling during shipping to maintain product integrity.