REVLIMID 25mg - Lenalidomide by Bristol Myers

    REVLIMID

    25mg
    Oncology Medications

    REVLIMID25mg

    REVLIMID (lenalidomide) 25mg is an immunomodulatory drug essential for treating multiple myeloma, myelodysplastic syndromes, and mantle cell lymphoma.

    Generic Name:Lenalidomide
    Manufacturer:Bristol Myers

    Key Benefits

    • Cornerstone of modern multiple myeloma treatment
    • Immunomodulatory drug with multiple mechanisms
    • Oral administration—convenient home treatment
    • Proven survival benefits in clinical trials
    • Effective both as induction and maintenance
    • Works in newly diagnosed and relapsed disease

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    How REVLIMID Works

    1

    REVLIMID is an immunomodulatory agent with multiple mechanisms of action:

    2

    **Immunomodulation:** Enhances T-cell and NK-cell activity against cancer cells. Stimulates production of IL-2 and IFN-γ, key cytokines for anti-tumor immunity.

    3

    **Direct Anti-Tumor Effect:** Binds to cereblon (CRBN), causing ubiquitination and degradation of transcription factors IKZF1 and IKZF3, which are essential for myeloma cell survival.

    4

    **Anti-Angiogenesis:** Inhibits VEGF and bFGF, reducing blood vessel formation that tumors need to grow.

    5

    **Microenvironment Disruption:** Decreases production of pro-inflammatory cytokines (TNF-α, IL-6) that support myeloma cell growth in the bone marrow.

    6

    This multi-targeted approach explains why REVLIMID is effective as both induction therapy and long-term maintenance, providing durable disease control.

    About REVLIMID 25mg

    REVLIMID (lenalidomide) 25mg by Bristol Myers Squibb (formerly Celgene) is a cornerstone immunomodulatory drug (IMiD) that has revolutionized multiple myeloma treatment. As the successor to thalidomide with improved efficacy and safety, REVLIMID has become an essential component of nearly every myeloma treatment regimen. REVLIMID works through multiple mechanisms: enhancing immune function, directly killing cancer cells, inhibiting angiogenesis, and modulating the bone marrow microenvironment. This multi-pronged action makes it remarkably effective against myeloma. REVLIMID is FDA-approved for multiple myeloma (in combination regimens for newly diagnosed and relapsed/refractory disease), maintenance therapy after autologous stem cell transplant, myelodysplastic syndromes with deletion 5q abnormality, and mantle cell lymphoma after two prior therapies. The FIRST trial demonstrated that continuous REVLIMID plus dexamethasone until progression significantly improved progression-free survival compared to fixed-duration chemotherapy. We provide authentic Bristol Myers Squibb REVLIMID for hematology/oncology centers and distributors worldwide.

    Common Uses

    • Multiple myeloma combination therapy
    • Myeloma maintenance after transplant
    • Myelodysplastic syndromes with del(5q)
    • Mantle cell lymphoma (relapsed/refractory)
    • Rd, VRd, DRd, KRd combination regimens

    Dosage Information

    Multiple Myeloma (with dexamethasone):

  1. 25 mg orally once daily on Days 1-21 of 28-day cycle
  2. Continue until disease progression
  3. Maintenance After Transplant:

  4. 10 mg once daily on Days 1-28 of 28-day cycles
  5. After 3 cycles, increase to 15 mg daily if tolerated
  6. MDS with del(5q):

  7. 10 mg orally once daily
  8. Mantle Cell Lymphoma:

  9. 25 mg once daily on Days 1-21 of 28-day cycle
  10. Dose Modifications:

  11. Based on blood counts (neutrophils, platelets)
  12. Reduce for renal impairment
  13. **CRITICAL:** REVLIMID is teratogenic. Available only through REMS program. Pregnancy prevention mandatory.

    Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.

    Storage & Handling

    Store REVLIMID capsules at 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C and 30°C (59°F and 86°F). Store in original packaging. No cold chain required.

    We ensure proper cold chain handling during shipping to maintain product integrity.

    Frequently Asked Questions About REVLIMID

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