OPDIVO
40mgOPDIVO40mg
OPDIVO (nivolumab) 40mg is a powerful PD-1 checkpoint inhibitor immunotherapy for treating melanoma, lung cancer, kidney cancer, and multiple other malignancies.
Key Benefits
- FDA-approved for 10+ cancer types
- Unique dual checkpoint blockade with YERVOY option
- Durable long-term responses possible
- Flexible dosing schedules (2-week or 4-week)
- Well-characterized safety profile
- Authentic Bristol Myers Squibb product
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How OPDIVO Works
OPDIVO works by blocking PD-1 (Programmed Death-1), a checkpoint protein on T-cells that normally acts as a "brake" on the immune system. Cancer cells exploit this pathway by expressing PD-L1 and PD-L2, which bind to PD-1 and suppress T-cell activity, allowing tumors to evade immune destruction.
By blocking PD-1, OPDIVO releases this brake and restores the T-cell's ability to recognize and kill cancer cells. This approach harnesses the body's natural immune defenses rather than using cytotoxic agents that damage both cancer and healthy cells.
When combined with YERVOY (ipilimumab), which blocks a different checkpoint called CTLA-4, the dual checkpoint blockade provides complementary mechanisms of immune activation, often resulting in higher response rates than either agent alone.
About OPDIVO 40mg
OPDIVO (nivolumab) 40mg/4mL and 100mg/10mL by Bristol Myers Squibb is a groundbreaking PD-1 immune checkpoint inhibitor that has revolutionized cancer treatment. As a fully human IgG4 monoclonal antibody, OPDIVO blocks the interaction between PD-1 and its ligands, unleashing the immune system's ability to fight cancer. OPDIVO is FDA-approved for numerous cancer types including unresectable or metastatic melanoma, non-small cell lung cancer, malignant pleural mesothelioma, renal cell carcinoma, classical Hodgkin lymphoma, squamous cell carcinoma of the head and neck, urothelial carcinoma, colorectal cancer with MSI-H/dMMR, hepatocellular carcinoma, esophageal cancer, and gastric cancer. OPDIVO is also approved in combination with YERVOY (ipilimumab) for enhanced efficacy in several indications, providing a dual checkpoint blockade approach. As a licensed pharmaceutical supplier, we provide authentic Bristol Myers Squibb OPDIVO with proper cold chain handling and competitive wholesale pricing for international healthcare providers.
Common Uses
- Melanoma (unresectable/metastatic and adjuvant)
- Non-small cell lung cancer
- Malignant pleural mesothelioma
- Renal cell carcinoma
- Classical Hodgkin lymphoma
- Head and neck squamous cell carcinoma
- Urothelial carcinoma
- MSI-H/dMMR colorectal cancer
- Hepatocellular carcinoma
- Esophageal cancer
- Gastric/GEJ cancer
Dosage Information
OPDIVO dosing varies by indication and whether used as monotherapy or in combination:
OPDIVO Monotherapy (most indications):
OPDIVO + YERVOY Combinations:
Dosing varies by cancer type. Common regimens include:
Administration:
Always refer to current prescribing information for specific indication-based dosing.
Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.
Storage & Handling
Store OPDIVO vials in the original carton to protect from light. Refrigerate at 2°C to 8°C (36°F to 46°F). Do not freeze. Do not shake.
The product may be held at room temperature (20°C to 25°C / 68°F to 77°F) for up to 8 hours including infusion time. The diluted solution may be stored at room temperature for up to 8 hours, or under refrigeration for up to 24 hours from the time of infusion preparation.
Do not store any unused portion of the infusion solution for reuse. Discard any remaining portion in the vial as the product does not contain preservatives.
We ensure proper cold chain handling during shipping to maintain product integrity.
Frequently Asked Questions About OPDIVO
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