LYNPARZA 150mg - Olaparib by AstraZeneca

    LYNPARZA

    150mg
    Oncology Medications

    LYNPARZA150mg

    LYNPARZA (olaparib) 150mg is a first-in-class PARP inhibitor for treating BRCA-mutated ovarian, breast, pancreatic, and prostate cancers with groundbreaking efficacy.

    Generic Name:Olaparib
    Manufacturer:AstraZeneca

    Key Benefits

    • First-in-class PARP inhibitor—pioneered a new treatment approach
    • Exploits synthetic lethality in BRCA-mutated cancers
    • Oral tablet—convenient at-home administration
    • Approved across ovarian, breast, pancreatic, and prostate cancers
    • 70% reduction in progression risk in BRCA+ ovarian cancer
    • Selectively targets cancer cells, sparing normal tissue

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    How LYNPARZA Works

    1

    LYNPARZA works by inhibiting poly(ADP-ribose) polymerase (PARP) enzymes, which are essential for repairing single-strand DNA breaks. In normal cells, if PARP is blocked, the homologous recombination (HR) pathway (which requires functional BRCA1/2 proteins) can compensate and repair DNA damage.

    2

    However, in cancer cells with BRCA1/2 mutations, the HR pathway is already defective. When LYNPARZA inhibits PARP in these cells, they cannot repair DNA damage through either pathway, leading to an accumulation of double-strand breaks, genomic instability, and ultimately cell death. This is called synthetic lethality—neither defect alone is lethal, but together they cause cell death.

    3

    This targeted mechanism means LYNPARZA selectively kills cancer cells with BRCA mutations while largely sparing normal cells, resulting in a favorable side effect profile compared to traditional chemotherapy.

    About LYNPARZA 150mg

    LYNPARZA (olaparib) 150mg tablets by AstraZeneca is the pioneering PARP inhibitor that revolutionized the treatment of BRCA-mutated cancers. As the first PARP inhibitor to receive FDA approval, LYNPARZA has established a new standard of care for patients with BRCA1/BRCA2 mutations across multiple cancer types. LYNPARZA exploits the concept of synthetic lethality—cancer cells with BRCA mutations already have defective DNA repair mechanisms. By inhibiting PARP (another DNA repair pathway), LYNPARZA creates a lethal accumulation of DNA damage specifically in cancer cells, leading to cell death while sparing normal cells. LYNPARZA is FDA-approved for maintenance treatment of BRCA-mutated advanced ovarian cancer, HER2-negative metastatic breast cancer with germline BRCA mutation, maintenance treatment of BRCA-mutated metastatic pancreatic cancer, and metastatic castration-resistant prostate cancer with homologous recombination repair gene mutations. Clinical trials have demonstrated remarkable efficacy—the SOLO-1 trial showed LYNPARZA reduced the risk of disease progression or death by 70% in newly diagnosed advanced ovarian cancer with BRCA mutation. We provide authentic AstraZeneca LYNPARZA with worldwide delivery for oncology centers and distributors.

    Common Uses

    • BRCA-mutated advanced ovarian cancer maintenance
    • gBRCA-mutated HER2-negative metastatic breast cancer
    • BRCA-mutated metastatic pancreatic cancer maintenance
    • HRR-mutated metastatic castration-resistant prostate cancer
    • First-line ovarian cancer maintenance with bevacizumab (HRD+)

    Dosage Information

    Standard Dosing (most indications):

  1. 300 mg (two 150mg tablets) taken orally twice daily
  2. Total daily dose: 600 mg
  3. Administration:

  4. Take approximately 12 hours apart
  5. Swallow tablets whole, do not chew, crush, or divide
  6. Can be taken with or without food
  7. Dose Modifications:

  8. First reduction: 250 mg twice daily
  9. Second reduction: 200 mg twice daily
  10. If further reduction needed, consider discontinuation
  11. Drug Interactions:

  12. Avoid strong/moderate CYP3A inhibitors
  13. Avoid strong/moderate CYP3A inducers
  14. Reduce dose with concomitant moderate CYP3A inhibitor
  15. Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.

    Storage & Handling

    Store LYNPARZA tablets at 20°C to 25°C (68°F to 77°F). Excursions permitted between 15°C and 30°C (59°F and 86°F). Store in original container. No cold chain required.

    We ensure proper cold chain handling during shipping to maintain product integrity.

    Frequently Asked Questions About LYNPARZA

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