KYPROLIS
60mgKYPROLIS60mg
KYPROLIS (Carfilzomib) 60mg is a second-generation irreversible proteasome inhibitor for relapsed or refractory multiple myeloma.
Key Benefits
- Nearly doubled PFS vs Velcade in ENDEAVOR (18.7 vs 9.4 months)
- Superior OS: 47.6 vs 40.0 months
- Dramatically lower neuropathy (6% vs 32%)
- KRd regimen: 87-97% ORR — NCCN Category 1
- Once-weekly option (ARROW trial)
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How KYPROLIS Works
Carfilzomib irreversibly binds to the 20S proteasome chymotrypsin-like activity (β5 subunit), blocking ubiquitin-mediated protein degradation. This causes accumulation of misfolded/damaged proteins, triggering ER stress, unfolded protein response, and ultimately apoptosis in myeloma cells.
About KYPROLIS 60mg
KYPROLIS (Carfilzomib) 60mg by Amgen is a breakthrough second-generation proteasome inhibitor that irreversibly binds to the 20S proteasome. The landmark ENDEAVOR trial demonstrated Kyprolis+Dex nearly doubled PFS vs Velcade+Dex (18.7 vs 9.4 months, HR=0.53) with superior OS (47.6 vs 40.0 months) and dramatically lower peripheral neuropathy (6% vs 32%). The KRd regimen (Kyprolis+Revlimid+dexamethasone) achieves 87-97% ORR and is an NCCN Category 1 preferred regimen. As a licensed pharmaceutical supplier, we provide authentic Amgen KYPROLIS with complete cold chain handling and competitive wholesale pricing.
Common Uses
- Relapsed or refractory multiple myeloma
- KRd regimen (with Lenalidomide + Dexamethasone)
- Kd regimen (with Dexamethasone alone)
- Frontline multiple myeloma (transplant-eligible, KRd)
Dosage Information
KRd: Cycle 1 Days 1,2: 20mg/m² IV, then 27mg/m² Days 8,9,15,16. Cycle 2+: 27mg/m² Days 1,2,8,9,15,16 of 28-day cycle. Kd (ENDEAVOR): 56mg/m². Hydration required. Infuse over 10-30 min.
Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.
Storage & Handling
Store at 2-8°C. Do not freeze. Reconstitute with 29mL SWFI (60mg vial). After reconstitution: stable 24h at 2-8°C or 4h at room temperature.
We ensure proper cold chain handling during shipping to maintain product integrity.
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