CALQUENCE
100mgCALQUENCE100mg
CALQUENCE (Acalabrutinib) 100mg is a second-generation, highly selective BTK inhibitor used to treat CLL, SLL, and mantle cell lymphoma.
Key Benefits
- Second-generation BTK inhibitor with highly selective binding
- Superior cardiovascular safety vs ibrutinib (ELEVATE-RR)
- 87% 4-year PFS in first-line CLL (ELEVATE-TN)
- Oral administration — convenient BID dosing
- Room temperature storage — no cold chain needed
- NCCN Category 1 preferred for CLL/SLL
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How CALQUENCE Works
Acalabrutinib selectively and irreversibly binds to Bruton's tyrosine kinase (BTK), blocking B-cell receptor (BCR) signaling. This inhibits malignant B-cell proliferation, adhesion, and migration, leading to apoptosis of CLL and MCL cells.
About CALQUENCE 100mg
CALQUENCE (Acalabrutinib) 100mg capsules by AstraZeneca is a breakthrough second-generation Bruton's tyrosine kinase (BTK) inhibitor designed for superior selectivity and improved cardiovascular safety compared to first-generation ibrutinib. FDA-approved for chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and relapsed/refractory mantle cell lymphoma (MCL). The ELEVATE-RR trial demonstrated non-inferior PFS to ibrutinib with significantly lower atrial fibrillation (9.4% vs 16.0%), while ELEVATE-TN showed an unprecedented 87% 4-year PFS rate in first-line CLL. As a licensed pharmaceutical supplier, we provide authentic AstraZeneca Calquence with competitive wholesale pricing for hospitals, hematology clinics, and pharmaceutical distributors worldwide.
Common Uses
- Chronic lymphocytic leukemia (CLL) — first-line and relapsed
- Small lymphocytic lymphoma (SLL)
- Relapsed/refractory mantle cell lymphoma (MCL)
- CLL with del(17p) or TP53 mutation
Dosage Information
100mg orally twice daily (every 12 hours). Swallow whole with water. With or without food. Continue until progression or unacceptable toxicity.
Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.
Storage & Handling
Store at 20-25°C (68-77°F). Excursions permitted 15-30°C. Protect from moisture. No refrigeration required.
We ensure proper cold chain handling during shipping to maintain product integrity.
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