HARVONI
90mg/400mgHARVONI90mg/400mg
HARVONI (Ledipasvir 90mg / Sofosbuvir 400mg) is an all-oral, once-daily fixed-dose combination tablet for the treatment of chronic Hepatitis C virus (HCV) infection, primarily Genotypes 1, 4, 5, and 6.
Key Benefits
- 94-99% cure rate (SVR12) across all studied populations
- All-oral, once-daily single tablet — no injections required
- 8-12 week treatment duration for most patients
- No interferon or ribavirin needed for most patients
- Well tolerated — minimal side effects compared to older regimens
- Effective in patients with compensated cirrhosis
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How HARVONI Works
Ledipasvir inhibits the NS5A protein, which is essential for HCV RNA replication, virion assembly, and secretion. Sofosbuvir is a prodrug that is metabolized to its active form (GS-461203), a uridine nucleotide analogue that inhibits NS5B RNA-dependent RNA polymerase by acting as a chain terminator. The combination targets two independent steps in the HCV lifecycle, providing a high barrier to resistance.
About HARVONI 90mg/400mg
HARVONI by Gilead Sciences revolutionized Hepatitis C treatment as the first single-tablet, all-oral regimen — eliminating the need for interferon injections and their severe side effects. This fixed-dose combination of Ledipasvir (an NS5A inhibitor) and Sofosbuvir (a nucleotide NS5B polymerase inhibitor) achieves cure rates (SVR12) of 94-99% across landmark ION clinical trials. With over 1.5 million patients treated worldwide since FDA approval in October 2014, Harvoni has one of the most extensive real-world safety and efficacy databases of any antiviral medication. Treatment duration is typically 8-12 weeks for most patients, transforming what was once a chronic, debilitating disease requiring 48 weeks of difficult therapy into a simple oral cure. As a licensed pharmaceutical supplier based in Turkey, we provide authentic Gilead Harvoni with full batch traceability, certificate of authenticity, and competitive wholesale pricing for hospitals, hepatology clinics, government health programs, and pharmaceutical distributors worldwide.
Common Uses
- Chronic Hepatitis C Genotype 1 (most common worldwide)
- Chronic Hepatitis C Genotype 4
- Chronic Hepatitis C Genotype 5
- Chronic Hepatitis C Genotype 6
- Treatment-naïve and treatment-experienced patients
- Patients with compensated cirrhosis (Child-Pugh A)
Dosage Information
One tablet (Ledipasvir 90mg / Sofosbuvir 400mg) once daily, with or without food. Treatment-naïve without cirrhosis: 8-12 weeks. With cirrhosis: 12 weeks. Treatment-experienced: 12-24 weeks depending on cirrhosis status.
Always consult with a qualified healthcare professional for proper dosing. This information is for reference only.
Storage & Handling
Store below 30°C (86°F) in original packaging. Protect from moisture. No cold chain required. Shelf life: 36 months from manufacture.
We ensure proper cold chain handling during shipping to maintain product integrity.
Frequently Asked Questions About HARVONI
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